Is Tweetbot for Mac accessible?

It indeed is accessible, and has some cool features. It just has a few minor issues, like there's no feedback for liking / unliking tweets, but its definitely usable.

I have both apps, and like you would like to find something better than Twitterrific, which does work relatively well has some UI decisions that could be better.

I really like Tweetbot's UI., which has 2 tables, one is a sidebar which has all your timelines and the other has the contents of whatever you selected, everything else can be accessed with menus or hotkeys. It's also a more actively developed app which has started switching to the newer Twitter API which gives things like streaming or attaching poles to your tweet.

There are a few accessibility annoyances that are keeping me from switching to it full time for now though.

Firstly, while I don't much care for how Mac Twitterrific reads posts, Tweetbot is worse, including the timestamp twice before the tweet text itself. An example of how VO reads a tweet is below:

42m 42 minutes ago, Picard management tip: Tell good stories. The right story can persuade, inspire, or illuminate., PicardTips, Picard Tips , retweet or quote button, like tweet button, user actions button, reply to tweet button, actions and sharing button, retweeted by Joseph King

There is no way to read media descriptions either. If a tweet has them, they're not spoken in the timeline and not visible if you open the media attachment. Something else that doesn't read at all, which is more serious, is direct messages. The most recent message is read if you're looking at the list of conversations, but once you click into one only the author gets read in the list of messages. Lastly, the filter dialog which lets you manage filtering rules has a lot of unlabeled controls so it's a bit difficult to use.

All that being said, despite Tapbot's shoddy record with accessibility I'm cautiously optimistic we might see some changes. The iOS app, while also not perfect has recently gained some big improvements, and I tweeted them about the Mac app's problems so we'll see what happens.

I switch between the two, because I really like Tweetbot because of it's notifications, even for home, it's general UI, etc, but it has some issues. The biggest one is that you can't read or write DMs properly. If you move from the text field it dies, and you can't read DMs at all. I wrote to the developers via email telling them about this, as well as a few other issues so we can hope it's fixed. Twitterrific has some issues too though. For example, the weird bug where sometimes text gets truncated or how multiple related tweets from the same user in a row doesn't read. I can confidently say that if Tweetbot fixed all it's issues, I'd fully switch.

I hadn't set up a second account in Tweetbot so wasn't aware of these issues you described, but thanks for letting people know here. Hopefully the developers will also see your comment.

That was another thing I couldn't figure out, and in fact didn't know you could even do it. What does the feature let you do? Would it, for example, let you move the timestamp after the text?