Understanding the Notification Centre

I was wondering if anyone has ever put together a short guide or podcast on understanding the Notification Centre? For example, how do the different options for a notification interact with Voice Over? Or, are there any particular options for notifications that we should or should not select for maximum effectiveness? I'm trying different things myself, but would appreciate any guidance that anyone more experienced would have to offer. I'd hate to think there was some small piece of advice I was missing that would make the whole thing even more worth-while! Incidentally, I'm using a 4th Gen Touch with iOS6 in case that's in any way relevant. Many thanks. Darran